Publication list
2024
43. A. Koller, O. Glaser, M. DeLuca, R. Motz, E. Amason, I. Carbo-Bague, J. Mixdorf, I. Guzei, E. Aluicio-Sarduy, D. Śmiłowicz, T. E. Barhart, C. Ramogida, E. Nolan, J. W. Engle, E. Boros. “"Off-Label" Use of Enterobactin Enables Targeted Imaging of Cancer with Radioactive Ti(IV)” Angew. Chem. Int. Ed. 2024, e202319578
42. J. N. Whetter, D. Śmiłowicz, E. Boros."Exploring Aqueous Coordination Chemistry of Highly Lewis Acidic Metals with Emerging Isotopes for Nuclear Medicine” Acc. Chem. Res. 2024, in press.
2023
41. M. Ma, E. Boros, J. J. Wilson. “The Inorganic Chemistry of Radiopharmaceuticals” Inorg. Chem. 2023, 62, 50, 20537–20538
40. R. Lengacher, K. E. Martin, D. Śmiłowicz, H. Esseln, P. Lotlikar, A. Grichine, O. Maury, E. Boros. “Targeted, Molecular Europium(III) Probes Enable Luminescence-Guided Surgery and 1 Photon Post-Surgical Luminescence Microscopy of Solid Tumors” J. Am. Chem. Soc. 2023, 145, 44, 24358–24366
39. A. Hu, K. E. Martin, D. Śmiłowicz, E. Aluicio-Sarduy, S. J. Cingoranelli, S. E. Lapi, J. W. Engle, E. Boros,J. J. Wilson. “Construction of the Bioconjugate Py-Macrodipa-PSMA and Its In Vivo Investigations with Large 132/135La3+ and Small 47Sc3+ Radiometal Ions” Eur. J. Inorg. Chem. 2023, e202300457
38. A. Marlin, A. Koller, E. Madarasi, M. Cordier, D. Esteban-Gómez, C. Platas-Iglesias, G. Tircsó, E. Boros, V. Patinec, R. Tripier. “H3nota Derivatives Possessing Picolyl and Picolinate Pendants for Ga3+ Coordination and 67Ga3+ Radiolabeling” Inorg. Chem. 2023, 62, 50, 20634–20645.
37. A. J. Koller, L. Wang, M. Deluca, O. Glaser, M. J. Robis, J. C. Mixdorf, M. N. Chernysheva, I. A. Guzei, E. Aluicio-Sarduy, T. E. Barhart, J. W. Engle, E. Boros. “De Novo Approaches to the Solid-Phase Separation of Titanium(IV) and Scandium(III): Translating Speciation Data to Selective On-Bead Chelation toward Applications in Nuclear Medicine” Inorg. Chem., 2023, 62, 50, 20655–20665.
36. K. E. Martin, A. J. Koller, E. Boros. “Radioactivity and U-235: An Educational Card Game to Introduce Nuclear Decay and the Benefits, Risks, and Safe Handling Strategies for Radionuclides” J. Chem. Educ., 2023, 100, 8, 3151–3155
35. D. Śmiłowicz, S. Eisenberg, R. LaForest, J.N. Whetter, A. Harriharan, J. Bordenca, C.J. Johnson, E. Boros. “Metal-Mediated, Autolytic Amide Bond Cleavage: A Strategy for the Selective, Metal Complexation-Catalyzed, Controlled Release of Metallodrugs” J. Am. Chem. Soc. 2023, 145, 29, 16261–16270
34. D. Śmiłowicz, S. Eisenberg, S. H. Ahn, A. J. Koller, P. P. Lampkin, E. Boros. “Radiometallation and photo-triggered release of ready-to-inject radiopharmaceuticals from the solid phase” Chem. Sci., 2023, 14, 5038-5055
33. K.E. Martin, J. A. Mattocks, D. Śmiłowicz, E. Aluicio-Sarduy, J. N. Whetter, J. W. Engle, J. A. Cotruvo, E. Boros. “Radiolabeling and in vivo evaluation of lanmodulin with biomedically relevant lanthanide isotopes” RSC. Chem. Biol., 2023, 4, 414-421
2022
32. Lengacher R, Cosby AG, Śmiłowicz A, Boros E. “Validation of a Post-Radiolabeling Bioconjugation Strategy for Radioactive Rare Earth Complexes with Minimal Structural Footprint” Chem. Commun., 2022, 58, 13728 - 13730 (This article is part of the themed Chem Comm collection: 2022 Emerging Investigators)
31. Lengacher R, Marlin A, Śmiłowicz D, Boros E. “Medicinal inorganic chemistry – challenges, opportunities and guidelines to develop the next generation of radioactive, photoactivated and active site inhibiting metal-based medicines”. Chem. Soc. Rev. 2022, 51, 7715-7731 This article is part of the themed Chem Soc Rev collection: 2022 Emerging Investigators
30. D. Śmiłowicz, D. Schlyer, E. Boros, L. Meimetis. Evaluation of a Radio-IMmunoStimulant (RIMS) in a Syngeneic Model of Murine Prostate Cancer and ImmunoPET Analysis of T-cell Distribution. Mol. Pharmaceutics 2022, 19, 9, 3217–3227
29. A. Pandey, M. Cao, E. Boros. Tracking Uptake and Metabolism of Xenometallomycins Using a Multi-Isotope Tagging Strategy. ACS Inf. Dis. 2022, 8, 878–888
28. A. J. Koller, S. Saini, I.F. Chaple, M.A. Joaqui-Joaqui, B. M. Paterson, M. T. Ma, P. J. Blower, V. C. Pierre, J. R. Robinson, S. E. Lapi, E. Boros. A General Design Strategy Enabling the Synthesis of Hydrolysis-Resistant, Water-Stable Titanium(IV) Complexes. Angew. Chem. Int. Ed. 2022, 61, e202201211. Also highlighted in ChemistryViews
27. J. N. Whetter, B. A. Vaughn, A. J. Koller, E. Boros An Unusual Pair: Facile Formation and In Vivo Validation of Robust Sc-18F Ternary Complexes for Molecular Imaging. Angew. Chem. Int. Ed. 2022, 61, e202114203. Hot Paper, highlighted in C&EN News.
2021
26. A. Pandey, D. Śmiłowicz, E. Boros. Galbofloxacin: A Xenometal-Antibiotic with Potent in vitro and in vivo Efficacy Against S. aureus. Chem Sci. 2021, 12, 14546 - 14556. Also read about this work in C&EN News and Chemistry World.
25. B.A. Vaughn, C.S. Loveless, S.J. Cingoranelli, D. Schlyer, S. E. Lapi, E. Boros, Evaluation of Lu-177 and Sc-47 Picaga-Linked, PSMA-targeting Constructs for Their Radiotherapeutic Efficacy and Dosimetry. Mol. Pharmaceutics. 2021, 18, 4511–4519
24. A. G. Cosby, J. J. Woods, P. Nawrocki, T. J. Sorensen, J. J. Wilson, E. Boros. Accessing Lanthanide-based, In Situ Illuminated Optical Turn-On Probes by Modulation of the Antenna Triplet State Energy. Chem. Sci. 2021, 12, 9442-9451
23. K. E. Martin, A. G. Cosby, E. Boros. Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer. J. Am. Chem. Soc. 2021, 143, 9206–9214
22. B. A. Vaughn, A. J. Koller, Z. Chen, S. H. Ahn, C. S. Loveless, S. J. Cingoranelli, Y. Yang, A. Cirri, C. J. Johnson, S. E. Lapi, K. W. Chapman, E. Boros. Homologous Structural, Chemical, and Biological Behavior of Sc and Lu Complexes of the Picaga Bifunctional Chelator: Toward Development of Matched Theranostic Pairs for Radiopharmaceutical Applications. Bioconjugate Chem. 2021, 32, 1232-1241
21. A. Pandey, E. Boros. Coordination Complexes to Combat Bacterial Infections: Recent Developments, Current Directions and Future Opportunities. Chem. Eur. J. 2021, 27, 7340-7350
2020
20. B. A. Vaughn, A. M. Brown, S. H. Ahn, J.R. Robinson, E. Boros. Is Less More? Influence of the Coordination Geometry of Copper(II) Picolinate Chelate Complexes on Metabolic Stability. Inorg. Chem. 2020, 59, 16095-16108
19. T. J. Sanderson, C. M. Black, J. W. Southwell, E. J. Wilde, A. Pandey, R. Herman, G. H. Thomas, E. Boros, A. K. Duhme-Klair, A. Routledge. A Salmochelin S4-Inspired Ciprofloxacin Trojan Horse Conjugate. ACS Infect. Dis. 2020, 6, 2532-2541
18. S. H. Ahn, J. Iuliano, E. Boros. Trivalent Metal Complex Geometry of the Substrate Governs Cathepsin B Enzymatic Cleavage Rate. Chem. Commun. 2020, 56, 7289-7292
17. C. C. Konkankit, B. A. Vaughn., Z. Huang, E. Boros, J. J. Wilson. Systematically altering the lipophilicity of rhenium(I) tricarbonyl anticancer agents to tune the rate at which they induce cell death. Dalton Trans. 2020, 49, 16062-16066
16. S. C. Marker, A. P. King, R. V. Swanda, B. A. Vaughn, E. Boros, S. B. Qian, J. J. Wilson. Exploring Ovarian Cancer Cell Resistance to Rhenium Anticancer Complexes. Angew. Chem. Int. Ed.. 2020, 59, 13391-13400
15. T. Kanagasundaram, C.S. Kramer, E. Boros, K. Kopka. Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging. Dalton Trans. 2020, 49, 7294-7298 selected as supplementary cover article
14. S. H. Ahn, B. A. Vaughn, W. A. Solis, M. L. Lupher, T. J. Hallam, Boros E. Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid Bioconjugate Chem. 2020, 31, 1177-1187.
13. E. Aluicio-Sarduy, N. A. Thiele, K. E. Martin, B. A. Vaughn, J. Devaraj, A. P. Olson, T. E. Barnhart, J. J. Wilson, E. Boros, and J. W. Engle. Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications Chem. Eur. J. 2020, 26, 1238-1242- selected as frontispiece
12. B. A. Vaughn, S. H. Ahn, E. Aluicio-Sarduy, J. Devaraj, A. P Olson, J. W. Engle and E. Boros. Chelation with a Twist: A Bifunctional Chelator to Enable Room Temperature Radiolabeling and Targeted PET Imaging with Scandium-44. Chem. Sci. 2020. 11, 333 - 342 - selected for Sci Pick of the Week/ HOT Article, Front cover article.
2019
11. A. Pandey, C. Savino, S. H. Ahn, Z. Yang, S. G. Van Lanen, E. Boros. Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency. J. Med. Chem. 2019, 62, 9947-9960.
10. E. E. Racow, J. Kreinbihl, A. G. Cosby, Y. Yang, A. Pandey, E. Boros, C. J. Johnson. A General Approach to Direct Measurement of the Hydration State of Coordination Complexes in the Gas Phase: Variable Temperature Mass Spectrometry. J. Am. Chem. Soc. 2019, 141(37), 14650-14660
9. A. G. Cosby, G. Quevedo, and E. Boros. A High-Throughput Method To Measure Relative Quantum Yield of Lanthanide Complexes for Bioimaging. Inorg. Chem. 2019, 58, 10611-10615
8. C. C. Konkankit, B. Vaughn, S. J. McMillan, E. Boros, J. J. Wilson. Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent. Inorg. Chem. 2019, 58, 3895-3909.
7. S. H. Ahn, D. Thach, B. Vaughn, V. Alford, A. Preston, S. T. Laughlin, E. Boros. Linear Desferrichrome-linked silicon-rhodamine antibody conjugate enables targeted multimodal imaging of HER2 in vitro and in vivo. Mol. Pharmaceutics 2019. 2019, 16, 1412–1420.
6. E. Boros, A. B. Packard. Radioactive transition metals for imaging and therapy. Chem Rev. 2019, 119, 870–901. Invited review for the Metals in Medicine special issue.
2018
5. A. G. Cosby, S. H. Ahn, E. Boros. Cherenkov Radiation Mediated In Situ Excitation of Discrete Luminescent Lanthanide Complexes. Angew. Chem. Int. Ed. 2018, 57, 15496-15499.
4. S. H. Ahn, E. Boros. Nuclear and Optical Bimodal Imaging Probes Using Sequential Assembly: A Perspective. Cancer Biother Radiopharm. 2018, 33, 308-315. Invited perspective.
3. E. Boros, J. P. Holland. Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers. J. Label. Compd. Radiopharm., 2018, 1-20. Invited review.
2017
2. K. M. Knopf, B. L. Murphy, S. N. MacMillan, J. M. Baskin, M. P. Barr, E. Boros, and J. J. Wilson. In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes, J. Am. Chem. Soc., 2017, 139, 14302–14314
1. C. J. Adams, J. J. Wilson, and E. Boros. Multifunctional Desferrichrome Analogues as Versatile 89Zr(IV) Chelators for ImmunoPET Probe Development Mol. Pharmaceutics, 2017, 14, 2831–2842.
Mentored work before Stony Brook - UBC, MGH/Harvard Medical School
2019
A. Rodríguez-Rodríguez, S. Shuvaev, N. Rotile, C. M. Jones, C. K. Probst, D. Dos Santos Ferreira, K. Graham-O′Regan, E. Boros, R. S. Knipe, J. W. Griffith, A. M. Tager, A. Bogdanov Jr., P. Caravan. Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation. ACS Sensors. 2019, 4, 2412-2419
2018
E. Boros, O. R. Pinkhasov, P. Caravan. Metabolite profiling with HPLC-ICP-MS as a tool for in vivo characterization of imaging probes. EJNMMI Radiopharm. Chem., 2018, 3, 2
2017
E. Boros, R. Srinivas, H.-K. Kim, A. M. Raitsimring, A. V. Astashkin, O. G. Poluektov, J. Niklas, A. D. Horning, B. Tidor, P. Caravan, Intramolecular Hydrogen Bonding Restricts Gd–Aqua-Ligand Dynamics. Angew. Chem. Int. Ed. 2017, 56, 5603.
2016
C. F. Ramogida, E. Boros, B. O. Patrick, S. K. Zeisler, J. Kumlin, M. J. Adam, P. Schaffer, C. Orvig. Evaluation of H 2 CHX dedpa, H 2 dedpa-and H 2 CHX dedpa-N, N′-propyl-2-NI ligands for 64 Cu (ii) radiopharmaceuticals. Dalton Trans., 2016,45, 13082-13090
N. Iki, E. Boros, M. Nakamura, R. Baba, and P. Caravan. Gd3TCAS2: An Aquated Gd3+-Thiacalix[4]arene Sandwich Cluster with Extremely Slow Ligand Substitution Kinetics. Inorg. Chem., 2016, 55, 4000–4005.
E. Boros, J. P. Holland, N. Kenton, N. Rotile, P. Caravan. Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of 89Zirconium for Positron Emission Tomography (PET) Imaging. ChemPlusChem 2016, 81, 274.
L. G. Meimetis, E. Boros, J. C. Carlson, C. Ran, P. Caravan, and R. Weissleder. Bioorthogonal Fluorophore Linked DFO—Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies. Bioconjugate Chem. 2016 27, 257-263
2015
E. Boros, E. M. Gale, P. Caravan. MR Imaging Probes: Design and Applications. Dalton Trans. 2015, 44, 4804-18.
E. Boros, A. M. Bowen, L. Josephson, N. Vasdev, J. P. Holland. Chelate-free metal ion binding and heat-nduced radiolabeling of iron oxide nanoparticles. Chem. Sci. 2015, 1, 225-36.
E. Boros, P. Caravan. Probing the Structure-Relaxivity Relationship of Bishydrated Gd(DOTAla) Derivatives. Inorg. Chem. 2015, 54, 2403-10.
C. F. Ramogida, J. F. Cawthray, E. Boros, C. L. Ferreira, B. O. Patrick, M. J. Adam, C. Orvig. H2CHXdedpa and H4CHXoctapa – Chiral Acyclic Chelating Ligands for 67/68Ga and 111In Radiopharmaceuticals. Inorg. Chem. 2015, 54, 2017–31.
2014
E. Boros, S. Karimi, N. Kenton, L. Helm, P. Caravan. Gd(DOTAlaP): Exploring the Boundaries of Fast Water Exchange in Gd-Based MRI Contrast Agents. Inorg. Chem. 2014, 53, 6985-94.
E. Boros,* E. Rybak-Akimova, J. P. Holland, T. A. Rietz, N. J. Rotile, F. Blasi, Day H, Latifi R, Caravan P. Pycup – A bifunctional, cage-like ligand for 64Cu radiolabeling. Mol. Pharmaceutics. 2014, 11, 617–29.
2013
D.T.T. Yapp, C. L. Ferreira, R. K. Gill, E. Boros, M. Q. Wong, D. Mandel, P. Jurek, G. E. Kiefer. Imaging Tumor Vasculature Noninvasively with Positron Emission Tomography and RGD Peptides Labeled with 64Cu using the Bifunctonal Chelates DOTA, Oxo-O3A and PCTA. Mol. Imaging. 2013, 12, 263-27.
E. Boros, P. Caravan. Structure relaxivity relationships of serum albumin targeted MRI probes based on a single amino acid Gd complex. J. Med. Chem. 2013, 56, 1782–6.
2012
E. Boros, M. Polasek, Z. Zhang, P. Caravan. Gd(DOTAla) – A single amino acid Gd-complex as a modular tool for high relaxivity MR contrast agent development. J. Am. Chem. Soc. 2012, 134, 19858–68.
G. A. Bayley, E. W. Price, B. M. Zeglis, C. L. Ferreira, E. Boros, M. J. Lacasse, B. O. Patrick, J. S. Lewis, M. J. Adam, C. Orvig. H2azapa: a Versatile Acyclic Multifunctional Chelator for 67Ga, 64Cu, 111In, and 177Lu. Inorg. Chem. 2012, 51, 12575–89.
C. L. Ferreira, D. T. Yapp, D. Mandel, R. K. Gill, E. Boros, M. Q. Wong, P. Jurek, G. E. Kiefer. 68Ga Small Peptide Imaging: Comparison of NOTA and PCTA. Bioconjugate Chem. 2012, 23, 2239–46.
E. Boros, J. F. Cawthray, C. L. Ferreira, M. J. Adam, C. Orvig. Evaluation of the H2dedpa Scaffold and its cRGDyK Conjugates for Labeling with 64Cu. Inorg. Chem. 2012, 51, 6279-84.
E. W. Price, J. F. Cawthray, G. A. Bailey, C. L. Ferreira, E. Boros, M. J. Adam, C. Orvig. H4octapa: An Acyclic Chelator for 111In Radiopharmaceuticals. J. Am. Chem. Soc. 2012, 134, 8670-83.
E. Boros, C. L. Ferreira, D. T. T. Yapp, R. K. Gill, E. W. Price, M. J. Adam, C. Orvig. Conjugates of the H2dedpa Scaffold: Synthesis, Labeling and Imaging with 68Ga. Nucl. Med. Biol. 2012, 39, 785-94.
2011
E. Boros, Y.-H. S. Lin, C. L. Ferreira, B. O. Patrick, U. O. Hafeli, M. J. Adam, C.Orvig. One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co. Dalton Trans. 2011, 40, 6253-59.
E. Boros, C. F. Ferreira, B. O. Patrick, M. J. Adam, C.Orvig. New Ga Derivatives of the H2dedpa Scaffold with Improved Clearance and Persistent Heart Uptake. Nucl. Med. Biol. 2011, 38, 1165-74.
2010
E. Boros, C. L. Ferreira, J. F. Cawthray, E. W. Price, B. O. Patrick, D. W. Wester, M. J. Adam, C. Orvig. Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration. J. Am. Chem. Soc. 2010, 132, 15726-33.
2009
E. Boros, U. O. Hafeli, B. O. Patrick, M. J. Adam, C. Orvig. Design, Synthesis, and Imaging of Small Amphiphilic Rhenium and 99mTechnetium Tricarbonyl Complexes. Bioconjugate Chem. 2009, 20, 1002-09