Publication list


E. E. Racow, J. Kreinbihl, A. G. Cosby, Y. Yang, A. Pandey, E. Boros, C. J. Johnson. A General Approach to Direct Measurement of the Hydration State of Coordination Complexes in the Gas Phase: Variable Temperature Mass Spectrometry. J. Am. Chem. Soc. 2019, in press.

A. G. Cosby, G. Quevedo, and E. Boros. A High-Throughput Method To Measure Relative Quantum Yield of Lanthanide Complexes for Bioimaging. Inorg. Chem. 2019, 58, 10611-10615

C. C. Konkankit, B. Vaughn, S. J. McMillan, E. Boros, J. J. Wilson. Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent. Inorg. Chem. 2019, 58, 3895-3909.

S. H. Ahn, D. Thach, B. Vaughn, V. Alford, A. Preston, S. T. Laughlin, E. Boros. Linear Desferrichrome-linked silicon-rhodamine antibody conjugate enables targeted multimodal imaging of HER2 in vitro and in vivo. Mol. Pharmaceutics 2019. 2019, 16, 1412–1420.

E. Boros, A. B. Packard. Radioactive transition metals for imaging and therapy. Chem Rev. 2019, 119, 870–901. Invited review for the Metals in Medicine special issue.


A. G. Cosby, S. H. Ahn, E. Boros. Cherenkov Radiation Mediated In Situ Excitation of Discrete Luminescent Lanthanide Complexes. Angew. Chem. Int. Ed. 2018, 57, 15496-15499.

S. H. Ahn, E. Boros. Nuclear and Optical Bimodal Imaging Probes Using Sequential Assembly: A Perspective. Cancer Biother Radiopharm. 2018, 33, 308-315. Invited perspective.

E. Boros, J. P. Holland. Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers. J. Label. Compd. Radiopharm., 2018, 1-20. Invited review.


K. M. Knopf, B. L. Murphy, S. N. MacMillan, J. M. Baskin, M. P. Barr, E. Boros, and J. J. Wilson. In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes, J. Am. Chem. Soc., 2017, 139, 14302–14314

C. J. Adams, J. J. Wilson, and E. Boros. Multifunctional Desferrichrome Analogues as Versatile 89Zr(IV) Chelators for ImmunoPET Probe Development Mol. Pharmaceutics, 2017, 14, 2831–2842.

Mentored work - UBC, MGH/Harvard Medical School


A. Rodríguez-Rodríguez, S. Shuvaev, N. Rotile, C. M. Jones, C. K. Probst, D. Dos Santos Ferreira, K. Graham-O′Regan, E. Boros, R. S. Knipe, J. W. Griffith, A. M. Tager, A. Bogdanov Jr., P. Caravan. Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation. ACS Sensors. 2019, in press.


E. Boros, O. R. Pinkhasov, P. Caravan. Metabolite profiling with HPLC-ICP-MS as a tool for in vivo characterization of imaging probes. EJNMMI Radiopharm. Chem., 2018, 3, 2


E. Boros, R. Srinivas, H.-K. Kim, A. M. Raitsimring, A. V. Astashkin, O. G. Poluektov, J. Niklas, A. D. Horning, B. Tidor, P. Caravan, Intramolecular Hydrogen Bonding Restricts Gd–Aqua-Ligand Dynamics. Angew. Chem. Int. Ed. 2017, 56, 5603.



C. F. Ramogida, E. Boros, B. O. Patrick, S. K. Zeisler, J. Kumlin, M. J. Adam, P. Schaffer, C. Orvig. Evaluation of H 2 CHX dedpa, H 2 dedpa-and H 2 CHX dedpa-N, N′-propyl-2-NI ligands for 64 Cu (ii) radiopharmaceuticals. Dalton Trans., 2016,45, 13082-13090

N. Iki, E. Boros, M. Nakamura, R. Baba, and P. Caravan. Gd3TCAS2: An Aquated Gd3+-Thiacalix[4]arene Sandwich Cluster with Extremely Slow Ligand Substitution Kinetics. Inorg. Chem., 2016, 55, 4000–4005.

E. Boros, J. P. Holland, N. Kenton, N. Rotile, P. Caravan. Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of 89Zirconium for Positron Emission Tomography (PET) Imaging. ChemPlusChem 2016, 81, 274.

L. G. Meimetis, E. Boros, J. C. Carlson, C. Ran, P. Caravan, and R. Weissleder. Bioorthogonal Fluorophore Linked DFO—Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies. Bioconjugate Chem. 2016 27, 257-263



E. Boros, E. M. Gale, P. Caravan. MR Imaging Probes: Design and Applications. Dalton Trans. 2015, 44, 4804-18.

E. Boros, A. M. Bowen, L. Josephson, N. Vasdev, J. P. Holland. Chelate-free metal ion binding and heat-nduced radiolabeling of iron oxide nanoparticles. Chem. Sci. 2015, 1, 225-36.

E. Boros, P. Caravan. Probing the Structure-Relaxivity Relationship of Bishydrated Gd(DOTAla) Derivatives. Inorg. Chem. 2015, 54, 2403-10.

C. F. Ramogida, J. F. Cawthray, E. Boros, C. L. Ferreira, B. O. Patrick, M. J. Adam, C. Orvig.  H2CHXdedpa and H4CHXoctapa – Chiral Acyclic Chelating Ligands for 67/68Ga and 111In Radiopharmaceuticals. Inorg. Chem. 2015, 54, 2017–31.



E. Boros, S. Karimi, N. Kenton, L. Helm, P. Caravan. Gd(DOTAlaP): Exploring the Boundaries of Fast Water Exchange in Gd-Based MRI Contrast Agents. Inorg. Chem. 2014, 53, 6985-94.

E. Boros,* E. Rybak-Akimova, J. P. Holland, T. A. Rietz, N. J. Rotile, F. Blasi, Day H, Latifi R, Caravan P. Pycup – A bifunctional, cage-like ligand for 64Cu radiolabelingMol. Pharmaceutics. 2014, 11, 617–29.



D.T.T. Yapp, C. L. Ferreira, R. K. Gill, E. Boros, M. Q. Wong, D. Mandel, P. Jurek, G. E. Kiefer. Imaging Tumor Vasculature Noninvasively with Positron Emission Tomography and RGD Peptides Labeled with 64Cu using the Bifunctonal Chelates DOTA, Oxo-O3A and PCTA. Mol. Imaging. 2013, 12, 263-27.

E. Boros, P. Caravan. Structure relaxivity relationships of serum albumin targeted MRI probes based on a single amino acid Gd complex. J. Med. Chem. 2013, 56, 1782–6.



E. Boros, M. Polasek, Z. Zhang, P. Caravan. Gd(DOTAla) – A single amino acid Gd-complex as a modular tool for high relaxivity MR contrast agent development. J. Am. Chem. Soc. 2012, 134, 19858–68.

G. A. Bayley, E. W. Price, B. M. Zeglis, C. L. Ferreira, E. Boros, M. J. Lacasse, B. O. Patrick, J. S. Lewis, M. J. Adam, C. Orvig. H2azapa: a Versatile Acyclic Multifunctional Chelator for 67Ga, 64Cu, 111In, and 177Lu. Inorg. Chem. 2012, 51, 12575–89.

C. L. Ferreira, D. T. Yapp, D. Mandel, R. K. Gill, E. Boros, M. Q. Wong, P. Jurek, G. E. Kiefer. 68Ga Small Peptide Imaging: Comparison of NOTA and PCTA. Bioconjugate Chem. 2012, 23, 2239–46.

E. Boros, J. F. Cawthray, C. L. Ferreira, M. J. Adam, C. Orvig. Evaluation of the H2dedpa Scaffold and its cRGDyK Conjugates for Labeling with 64Cu. Inorg. Chem. 2012, 51, 6279-84.

E. W. Price, J. F. Cawthray, G. A. Bailey, C. L. Ferreira, E. Boros, M. J. Adam, C. Orvig. H4octapa: An Acyclic Chelator for 111In Radiopharmaceuticals. J. Am. Chem. Soc. 2012, 134, 8670-83.

E. Boros, C. L. Ferreira, D. T. T. Yapp, R. K. Gill, E. W. Price, M. J. Adam, C. Orvig.  Conjugates of the H2dedpa Scaffold: Synthesis, Labeling and Imaging with 68Ga. Nucl. Med. Biol. 2012, 39, 785-94.



E. Boros, Y.-H. S. Lin, C. L. Ferreira, B. O. Patrick, U. O. Hafeli, M. J. Adam, C.Orvig. One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co. Dalton Trans. 2011, 40, 6253-59.

E. Boros, C. F. Ferreira, B. O. Patrick, M. J. Adam, C.Orvig. New Ga Derivatives of the H2dedpa Scaffold with Improved Clearance and Persistent Heart Uptake. Nucl. Med. Biol. 2011, 38, 1165-74.



E. Boros, C. L. Ferreira, J. F. Cawthray, E. W. Price, B. O. Patrick, D. W. Wester, M. J. Adam, C. Orvig.  Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration. J. Am. Chem. Soc. 2010, 132, 15726-33.



E. Boros, U. O. Hafeli, B. O. Patrick, M. J. Adam, C. Orvig.  Design, Synthesis, and Imaging of Small Amphiphilic Rhenium and 99mTechnetium Tricarbonyl Complexes. Bioconjugate Chem. 2009, 20, 1002-09